The general M.O.D.O.C. technology and evolutionary accelerator chamber has been used for various derivative experiments by A.I.M. over the years. Chief among them was S.O.D.A.M., who briefly posed as Hank Pym’s first wife Maria, with an enormous brain mass but otherwise possessing normal proportions. [Solo Avengers #18] She later mutated further into a more traditional M.O.D.O.K. design and was renamed M.O.D.A.M. [Captain America (1st series) #388] Kathryn Waynesboro was also mutated briefly into a Ms. M.O.D.O.K. form by A.I.M. [Incredible Hulk (2nd series) #290] One A.I.M. division created M.O.D.O.T., Mental Organism Designed Only for Talking, who became obsessed with controlling the world through manipulation of mass media. [Howard the Duck (4th series) #1] There was also M.O.D.O.R.G., the Mental Organism Designed Only for Roller Derby, who appeared in a plot by the Chadmaster to compete with Dazzler and the Daughters of the Dragon. [X-Men: To Protect and Serve #4] At the other end of the spectrum, a more extremist version of A.I.M. known as A.G.M., Advanced Genocide Mechanics, created M.O.D.O.G., the Mental Organism Designed Only for Genocide. [Invincible Iron Man (1st series) #2] A mass effort at innovating the technology came from the M.O.D.O.C. Squad, Military Operatives Designed Only for Combat [Captain America (5th series) #8], the Super-M.O.D.O.K. Squadron [Captain America: Reborn #5], and the M.O.G.O.D., Microscopic Oddities Generated Only for Disintegration. [A+X #4]
In the Ultimate universe, Dr. George Armstrong Tarleton was a scientist for A.I.M. operating from the Kailasa space station. In his dreams of scientific perfection and conquest, Doctor Tarleton rebuilt his body as a cybernetic organism. Kailasa station captured a dormant drone from the Gah Luk Tus swarm as it was driven away from Earth. Tarleton hoped to connect the raw genocidal power of Gah Lak Tus to his cybernetics and hold the Earth for ransom. To accomplish this, he lured Vision, harbinger of Gah Lak Tus, to Kailasa station with a plan to use her to communicate with the swarm drone and find its self-destruct sequence. After using and disposing of Vision, Tarleton repowered the drone and incorporated some of its exotic tech into his cybernetic nervous system, only to fall under the sway of Gah Lak Tus and its mission of genocide. Vision failed to stop Tarleton and the drone from annihilating Kailasa station and returning to its mission of destroying Earth. Vision did free Tarleton’s mind, allowing the egomaniac to think for himself again, and they dismantled the Gah Lak Tus drone.
Tarleton was left headless and abandoned for dead in the desert after the battle with the drone. He recovered and began calling himself M.O.D.O.K., his cybernetically-preserved head able to operate independently and move between bodies. M.O.D.O.K. reconnected with A.I.M. and converted it into a Cult of Gah Lak Tus. When Earth-616’s Galactus came to Earth-1610 and merged with the Gah Lak Tus swarm, Tarleton was prepared to serve as its Herald, spreading the word of Gah Lak Tus on Earth in an effort to remain alive in the future. He unleashed a cyber-virus in Belarus to convert others to his twisted gospel and assumed control of the City of Tomorrow once overseen by Reed Richards. Tarleton was opposed by Falcon and Nick Fury’s agents of S.H.I.E.L.D., as his twisted crusade was brought to an end. His head was crushed by Hercules, and Agent Danny Ketch sacrificed himself to end the Gah Lak Tus swarm’s influence on the infected innocents.
In Future Imperfect, a terrorist group initiated World War III between the United States and Russia, leading to nuclear devastation and fallout as 60% of humanity died. The lingering effects were helped along by a nihilist group called the Black Scythe who unleashed bio-weapons on the remaining populace. M.O.D.O.K. and A.I.M. captured a number of radiation-based super-beings like the Hulk and the Abomination in an effort to extrapolate their resistance to radiation for others to use. A.I.M. entered a bunker mentality and became survivalists deep under Los Angeles until the atmosphere was theoretically safe to breathe again. Decades passed, however, and life on the surface wasteland did not get better. In time, the machinery keeping the Hulk in stasis failed, and he escaped. A.I.M. was later destroyed in a missile strike during a conflict between the Pantheon and the Maestro, Hulk’s new persona.
On Earth X, the awakening of the Skull’s psychic power was enough to instantly kill all telepaths on Earth, including M.O.D.O.K. The Skull would later get a hold of M.O.D.O.K.’s Doomsday Chair, using it as his personal throne during his procession across America.
In Heroes Reborn, a new version of M.O.D.O.K. existed in Franklin Richards' constructed reality. He and A.I.M. made an alliance with Baron Zemo to attack the S.H.I.E.L.D. Helicarrier. They found themselves facing Captain America and a displaced Cable. M.O.D.O.K. was unprepared to face another telepath like Cable and fell before the mutant’s mental might. Loki would later confront M.O.D.O.K. while in S.H.I.E.L.D. custody, for his own purposes.
In the Squadron Supreme’s Heroes Reborn of 2021, the Mental Organism Designed Always to Conquer, or M.O.D.A.C., was a foe to Doctor Spectrum. He sought the Omega Stone at a museum in Carefree, Arizona, but was opposed by his nemesis. M.O.D.A.C. used the Stone to enhance his powers and separate Spectrum from his Power Prism. Young Sam Alexander raced to his hero’s aid and touched the Power Prism, severing M.O.D.A.C.’s hold on it and going on to become Kid Spectrum.
In the domain of Battleworld known as Killville, there were no heroes, only villains and gangs squabbling for power and territory over the helpless citizenry. M.O.D.O.K. was a genius scientist and compulsive murderer whose usefulness to the domain’s Baron Mordo only barely exceeded the desire of nearly everybody to have him killed. M.O.D.O.K. did as he liked without regard for the Baron, the Assassins Guild or anybody else. While at the borders of the Sentinel Territories, M.O.D.O.K. witnessed the Thor named Angela struck down and deprived of her hammer. Against all odds, M.O.D.O.K. did not immediately try to kill her, but fell in love instead.
M.O.D.O.K. and Angela uncovered a scheme by Baron Mordo to lure Sheriff Stephen Strange to Killville, murder him, and claim his position. When M.O.D.O.K. uncharacteristically did not kill Angela, the scheme fell apart. Mordo was turned over to the Thors, and M.O.D.O.K. was instated as the new Baron of Killville on Doom’s authority. Though she did not return his love, Angela acknowledged M.O.D.O.K. at least as a kindred spirit on the field of battle.
Elsewhere on Battleworld, a version of M.O.D.O.K. in The Iron became tired of constantly being failed by his incompetent minions. He created the Tarleton Transporter to summon M.O.D.O.K.s from other domains and forge an alliance. Together, these M.O.D.O.K.s would help M.O.D.O.K. the Iron supplant God Doom and he would then magnanimously install them as Barons of their respective domains for their aid. The M.O.D.O.K.s began to quibble over which of them was truly the most evolved intellect, and a fight broke out. By the time the Thors arrived to arrest M.O.D.O.K. the Iron for heresy, the collective M.O.D.O.K.s had killed or beaten each other unconscious.