In Daredevil: End of Days, Maya Lopez retired from crime-fighting after witnessing a particularly hard night for Daredevil. She got her Masters' degree and became a professor teaching at a Manhattan university, specializing in classes on pattern recognition. After Daredevil died fighting Bullseye, Ben Urich spoke to Maya while making his rounds to uncover the truth behind Matt Murdock's final days.
In What If..? Daredevil vs. Elektra, Matt Murdock died trying to rescue Hugo Natchios at Colombia University. He was resurrected by the Hand to become their greatest champion, the Advocate. Meanwhile, Elektra followed the path of justice and eventually became an agent of S.H.I.E.L.D. After taking over the Hand, the Advocate murdered the Kingpin, Bullseye, and many other threats. Maya Lopez was still Fisk's ward, and she joined Elektra's new incarnation of the Chaste (calling herself "Seer") to fight against the Advocate's Hand.