The Mental Organism Designed Only for Killing, M.O.D.O.K. is a sight to remember. Created by Advanced Idea Mechanics as a living computer, M.O.D.O.C. changed his acronym from "Computing" and seized power from his creators. Literally programmed to kill, M.O.D.O.K.'s proclivities are often at odds with the logical power of his intellect. Able to inspire fear but not loyalty, M.O.D.O.K. has spent much of his career dealing with betrayals and in-fighting among A.I.M. factions trying to remove him from control. The ascension of Andrew Forson as Scientist Supreme drove M.O.D.O.K. into the arms of S.H.I.E.L.D., joining his greatest foes as part of the Secret Avengers Initiative. Despite finding common ground with Maria Hill, M.O.D.O.K.'s programming caused him to return to his murderous lifestyle.

Bushwacker's origin is an odd example of a mutant plotline continuing in non-X-Titles. After the Mutant Massacre, Bushwacker was reportedly hired by the Marauders to continue assassinating mutants on their behalf. An assassin who was really a serial killer who saw himself as an artist, Bushwacker targeted low-level mutants whose abilities helped them become incredible writers, artists, ballerinas, and so on. He was confronted by Daredevil and Wolverine, and would go on to threaten the Punisher. During the Initiative, Bushwacker became a member of the Hood's growing criminal syndicate, and he also fought X-Force after joining Belladonna and the Assassins Guild. Privately, Bushwacker was a sea of self-doubt and conflicting impulses, a failed priest, failed CIA agent, and failed husband. He once even claimed to be a mutant despite the obvious cybernetic elements of his gun arms, a sign of how deep his envy and psychosis really went.